VIB Center for Molecular Neurology

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Science Director: Christine Van Broeckhoven

Mission statement

The overall objective of the VIB Center for Molecular Neurology (CMN) is to enhance our current understanding of the biology of the nervous system during healthy aging and in relation to aging-related diseases. The new information will be translated to the clinic as well as to experimental work to gain a comprehensive view of the disease process ultimately contributing to the development of effective preventive interventions and etiological treatments. To achieve this objective, CMN defines two main goals: i) to improve our knowledge on the complex molecular etiology of age-related neurological diseases and ii) to create effective translational pipelines and potential therapies that are specifically tailored to well-characterized patient groups. In this way, the CMN’s mission will thrive on and complement the strategic initiative of VIB on translational research, adding to the visibility and raising further the international standing of our institute.

Specific aims

1. To identify causal genes and disease modifying genes that contribute to genetic risk and clinical expression.

2. To analyze the clinical trajectory, including the early asymptomatic phase of disease, in large families with inherited disease.

3. To unravel the molecular mechanisms underlying the onset and progression of disease.

4. To generate a holistic understanding of age-related neurological diseases by discovering genetic, epigenetic, transcriptomic, and proteomic signatures of disease amenable to therapeutic targeting.

5. To develop translationally-effective cell and animal models of disease for mechanistic investigation, diagnostic interpretation and therapeutic intervention.

6. To identify (noninvasive) biomarkers and therapeutic strategies for personalized medicine.

©2017 VIB Center for Molecular Neurology